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Foundayo
Foundayo is a prescription pill approved by the U.S. Food and Drug Administration (FDA) to help adults with obesity, or overweight with a weight-related medical problem, lose weight and keep it off.
Foundayo is a brand name for orforglipron, a once-daily oral GLP-1 receptor agonist manufactured by Eli Lilly. Unlike the injectable GLP-1s, it is a small-molecule tablet rather than a peptide.
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Foundayo activates the GLP-1 receptor, the same target as the injectable GLP-1 medications. That slows digestion, helps regulate appetite and blood sugar, and signals fullness to the brain.
Because it is absorbed without the food and water restrictions of earlier GLP-1 pills, it can be taken at any time of day. Doses step up over several months from 0.8 mg to a 14.5 mg or 17.2 mg maintenance dose.
Foundayo should not be combined with other GLP-1 medicines, and like the rest of the class it may require long-term use for continued benefit.
Expected weight loss depends on the dose and your lifestyle.
In a 72-week study of adults without diabetes funded by Eli Lilly, average weight loss was 7.4% on 5.5 mg, 8.3% on 9 mg and 11.1% (about 25 pounds) on 17.2 mg, compared with 2.1% on placebo, alongside a reduced-calorie diet and increased physical activity.
As a tablet, Foundayo needs no injections, no refrigeration and no planning around meals, which many patients find easier to stay on.
$149/mo for the pill · Where a new Foundayo prescription begins.